Diabetes Immunogenetics

A complex interaction of both genetic and immunologic factors leads an autoimmune disease Type 1 diabetes mellitus (T1DM). T1DM usually has a relapsing remitting disease course with autoantibody and T cellular responses to islet autoantigens, which precede the clinical onset of the disease process. The immunological diagnosis of autoimmune diseases relies primarily on the detection of autoantibodies in the serum of T1DM patients. Although their pathogenic significance remains uncertain, they have the practical advantage of serving as surrogate biomarkers for predicting the clinical onset of T1DM.

  • Immunopathogenesis of type 1A diabetes
  • T lymphocytes
  • Autoantibodies and autoimmune disease
  • Development and evaluation of preventive therapies
  • Insulin autoimmunity as a cause of hypoglycemia

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