Immunomics

Immunomics is an investigation of Immunome research  by utilizing genome wide methodologies. It is  the study of immune system regulation and response to pathogens using genome-wide approaches. With the assistance of genomics and proteomic technologies or innovations, the invulnerable systems and the capacities were considered. The research could  been able to visualize biological networks and infer interrelationships between genes and/or proteins. Recently, these technologies have been used to help better understand how the immune system functions and how it is regulated. Immunomics is a relatively new field of research which integrates the disciplines of immunology, genomics, proteomics, transcriptomics and bioinformatics to characterize the host-pathogen interface. Discussions on the rapid advances in molecular immunology, sophisticated tools and molecular databases are facilitating in-depth exploration of the Immunome. In our opinion, an immunomics approach presides over traditional antigen and vaccine discovery methods that have proved ineffectively for highly complex pathogens such as the causative agents of malaria, tuberculosis and schistosomiasis that have evolved genetic and immunological adaptations. By using an integrative multidisciplinary approach, immunomics offers enormous potential to advance the  21st century antigen discovery and rational vaccine design against complex pathogens such as the Plasmodium parasite. Two thirds of the genome is active in one or more immune cell types and less than 1% of genes are uniquely expressed in a given type of cell. Therefore, it is critical that the expression patterns of these immune cell types be deciphered in the context of a network, and not as an individual, so that their roles be correctly characterized and related to one another.

  • Rational vaccine design
  • Vaccine development
  • Antigen recovery
  • Use of technologies in immunomics

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